In 2003, Maher launched a new show, Real Time with Bill Maher on HBO. Maher also created Politically Incorrect, which aired on Comedy Central. Maher brought together some of the most interesting politicians, entertainers and journalists to participate in some of the most controversial, topical and comical discussions. A cutting edge contender of provocative late night television, Politically Incorrect survived for five years on ABC. Politically Incorrect received a total of 18 Emmy nominations since 1995.

Maher, inspired by the show’s success, assembled some of “PI’s” most memorable highlights in his book Does Anybody Have a Problem With That? Maher brought his tongue-in-cheek commentaries on such modest proposals as putting warning labels on the Bible, why we should have drunk driving lanes, and his regular “Get Over Yourself Award,” given to such notables as Newt Gingrich, Santa Claus, and the O.J. Simpson defense team. He also offers a collection of some of the funniest and most insightful thoughts of “PI’s” panelists, including Ben Affleck, Marilyn Manson, Ann Richards, Pamela Anderson, Oliver Stone, Ron Howard, Arianna Huffington, and Janeane Garofalo.

In conjunction with the release of Maher's book When You Ride Alone You Ride With Bin Laden, Maher went on a nationwide stand-up tour and drew standing ovations for his hilarious routine. Maher’s credits include five HBO specials, including the critically acclaimed Bill Maher: Be More Cynical. Maher has participated in comedy tours throughout the United States. Last year he received a Tony nomination for the three-week run of his one-man Broadway show, Victory Begins at Home.